2.2 Rise of the Omics
Discussion-
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How have advancements in omic technologies (genomics, transcriptomics, proteomics) enabled us to study small, hard-to-collect, and/or rare venomous animals? How will these technologies dramatically expand the reservoir of venoms that can be explored in drug discovery?
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July 5, 2022 at 7:29 pm
It’d allow more dimensions of biochemical analysis to get more information out of smaller samples and would continue to do so for less studied venoms as well as the metabolism of those venoms.
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September 17, 2022 at 8:28 am
RNA is extracted from the source. This is put into the OMEC.
This allows the 20 amino acids to be identified.
The way the OMEC revolutionizes can be seen in a bio of Saddam Hussein and his chemical weapons. Possibly natural venoms are better tools than man-made.
Drug discoveries go to libraries when the venom is in OMEC. This allows world wide researches, often not on target to occur.
This has huge applications, some genocidal.
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December 13, 2022 at 9:38 pm
la extraccion de pequeñas muestras, mediante ampliacion genomica con PCR, podrian ser de mucha utilidad
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December 14, 2022 at 11:30 am
These technologies have greatly increased the efficiency of proteomics because they allow us to study smaller molecules with more precision. This results in more potential drugs due to the increased findings.
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March 4, 2023 at 5:14 pm
These new and modern type of technologies we can study smaller molecules and samples with bigger efficiency
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April 5, 2023 at 8:30 am
Does this mean it will be easier to extract venom from “smaller” creatures such as insects. Are there any venoms or fluids from insects which is repellant to insects? Like not mortal but “disgusting” for insects so they leave the premesis? Are those regarded as venoms?
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January 5, 2025 at 11:01 am
You forgot to mention the LC component of the LC/MS. Is the MS example you displayed from one component or from the complete mixture of compounds?
Also MS gives very limited structural information. There are methods available which would allow you to crystallize these proteins and carry out x-ray diffraction. Have you done this? X-ray could also be employed to examine these proteins bound to the receptor, are you trying this? I have references to this methodology if you are interested.
NMR could also be used for structure determination.
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