World Science Scholars

3.3 Your Concerns about Germline Editing

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    • While we’ve covered many safety and technical issues with CRISPR-based embryo editing, there are also several ethical and societal concerns that arise, including the lack of consent given by the “patients”, and the potential to exacerbate discrimination and genetic inequalities. Given the safety, technical, and ethical concerns, weigh in on what troubles you the most. Alternatively, perhaps some of you may feel that the concerns are overblown and/or overshadowing the exciting future possibilities. Why not edit DNA in embryos to make humans healthier and less prone to disease/infection?

      In the discussion area, contribute your opinions on the general topic of embryo editing:

      • What gives you the most unease about a future world in which germline editing becomes commonplace?
      • Which concerns, if any, do you think are misplaced or poorly supported?
      • If it were possible to safely and precisely edit embryos to confer lifelong HIV resistance, à la the experimental approach of Dr. Jiankui He, is this something we should pursue as a society? Why or why not?

      Once you’ve submitted your thoughts, review other comments and think about what people agree and disagree on. How much do their opinions differ from yours? Is there a general consensus?

    • Germaine editing since it stays forever in future generations

    • Misplaced concerns are for developing designer babies since the complexity is too high to achieve this

    • If we have precise method and proven safety then we should pursue.

    • If designer babies are possible, then the richer you are the more “editable” your kid will be and the most advantages he or she will have. Therefore, the rich will win not just in this life, but in their kids’ lives and the genetic “lottery”. Basically, the rich would become more and more “perfect” due to their increased ability to edit away unfavorable genes for their children (of course, assuming this really works and it’s safe).

      However, the counter argument is that it would be immoral to be able to avoid a children’s disease and not do it “due to moral reasons”. I am in favor of doing it and we should make this technology safe and cheap so that sufferring due to genetic abnormalities is minimized.

      • Fortunately, their idea of perfect will eventually exclude actual advantages.

    • As always with scientific discovery, the danger lies not in its use to improve people´s lives, but in its possible ABUSE by unscrupulous scientists working for even more unscrupulous governments who only have their own interests in mind.
      This being said, as with all the other discoveries, there is no stopping progress, and eventually the CRISPR technology will also be used for both good and evil. This, to me, is an unsettling thought.

    • Mass mandates with limited disclosure for consent scare the life purpose out of me, and while I find the concept of designer babies intriguing, the excessively success striving parent types could take it too far in a progression of power derived from it in private wealth. I think we all need to learn how to just love each other as they are and for all differences that arise in everyone and admire the science that could have such power to control from afar behind museum glass unless it’s needed to prevent a heritable condition like progeria.

    • Concerns with CRISPER Cas9 are making a Nazi super race.

      Usually non- human efforts genocide humanity.

      Adding super immunity to embryos is something that mother`s milk usually does, so immunize the mother first.

    • What gives you the most unease about a future world in which germline editing becomes commonplace?
      If such a thing were to happen, there would be an ultimate race to create the perfect designer baby. The richer someone is, the better prospects of them of having their ideal designer baby. Industry sectors or academic sectors even would no longer be able to differentiate between the potentials of each designer baby as all of them would typically have traits that dominate. The concept of giving all a fair chance will eventually eradicate. Creating designer babies will reduce the relation of a child to their parents as they will lose the traits that associate them to their ancestors.

      Which concerns, if any, do you think are misplaced or poorly supported?
      Ethical concerns in case of germline editing are potentially the biggest concern. Not everyone would agree to creating designer individuals. There are also high risks involved – procedure may not go as planned, there could be chances of mutations occurring during the procedures itself.

      If it were possible to safely and precisely edit embryos to confer lifelong HIV resistance, à la the experimental approach of Dr. Jiankui He, is this something we should pursue as a society? Why or why not?
      I think if the means used is safe and targeted towards a disease such as HIV, then we must pursue it as a society. We are on the voyage to eradicating diseases as much as we can. However, there are also ethical norms and concerns that must be taken care of before such procedures are delved with.

    • Most unease: germline editing being monetized and out of reach for the majority, leading to a larger gap between the wealthy and non-wealthy, as some people can afford to give their future children every possible benefit. Also potential for abuse of this technology.

      Misplaced concerns- none. I think it’s important to be concerned about the possibilities.

      If it were possible to safely and precisely edit embryos to confer lifelong HIV resistance, à la the experimental approach of Dr. Jiankui He, is this something we should pursue as a society? Why or why not? Absolutely, but make it achievable for all, and the research needs to be there first to ensure safety.

    • Concern: editing may have side effects. Those may only show in adults.
      Other issues: who is to decide what is permitted?
      And who is going to pay for it? Or is availability of such technology fostering difference.

    • worry

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