1.2 From Biology to Computer Science Summary
- Humans have been altering biology for thousands of years through artificial selection.
- Genetically engineered products are now contributing US$400 billion to the GDP.
- Examples include E. Coli engineered to produce hydrocodone and papaya engineered to resist the ringspot virus.
- Professor Endy researches how to engineer living matter and what impact it could have.
- To systematically improve at engineering something, we go through iterative Design-Build-Test cycles.
- To make this process more efficient, Endy used DNA synthesis to separate design and construction, set technical standards, and developed ways to manage the complexity of biology.
- Professor Endy’s group created the “flipee,” the first synthetic biological logic gate that flips DNA.
- The flipee design process took three years and 700 design attempts.