World Science Scholars
3.4 Multiple Ways of Making a Cortex
  • There are multiple ways for cortical volume to occupy three-dimensional space and this varies across species. 
  • In turn, there are also multiple ways to distribute cortical neurons in three-dimensional space. 
  • Larger cortices are not necessarily more folded than smaller ones. 
  • The degree of folding of a cortex is subject to physical principles: folding increases as the effective free energy of the growing volume and its surface is minimized.
  • Cortical folding scales universally with surface area and thickness. Folding is not dependent on the number of neurons.

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